✦ LIBER ✦

Drug-induced cholestasis

✍ Scribed by Manmeet S. Padda; Mayra Sanchez; Abbasi J. Akhtar; James L. Boyer

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 442 KB
Volume: 53
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.24229

No coin nor oath required. For personal study only.

✦ Synopsis

Recent progress in understanding the molecular mechanisms of bile formation and cholestasis have led to new insights into the pathogenesis of drug-induced cholestasis. This review summarizes their variable clinical presentations, examines the role of transport proteins in hepatic drug clearance and toxicity, and addresses the increasing importance of genetic determinants, as well as practical aspects of diagnosis and management.

📜 SIMILAR VOLUMES

Hepatobiliary transporters and drug-indu

Hepatobiliary transporters and drug-induced cholestasis

✍ Christiane Pauli-Magnus; Peter J. Meier 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 348 KB

Drug-induced liver injury is an important clinical problem with significant morbidity and mortality. Whereas for most hepatocellular forms of drug-induced hepatic injury the underlying pathophysiological mechanism is poorly understood, there is increasing evidence that cholestatic forms of drug-indu

Drug-induced hepatic cholestasis in the

Drug-induced hepatic cholestasis in the critically ill

✍ Anne Julie Frenette; Marie-Eve Bédard Dufresne; Valérie Bonhomme; Martin Albert; 📂 Article 📅 2011 🏛 Springer 🌐 English ⚖ 138 KB

Drug-induced hepatic cholestasis in the

Drug-induced hepatic cholestasis in the critically ill

✍ Anne Julie Frenette; Marie-Eve Bédard Dufresne; Valérie Bonhomme; Martin Albert; 📂 Article 📅 2011 🏛 Springer 🌐 English ⚖ 138 KB

Sepsis-induced cholestasis

✍ Nisha Chand; Arun J. Sanyal 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 404 KB

Sepsis-induced cholestasis

✍ Kurt Lenz; Christine Kapral; Fritz Firlinger; Fritz Wewalka 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 45 KB

Hepatic dysfunction and jaundice is a common finding in patients with septic shock. In their excellent review, Dr. Nisha Chand and Prof. Arun J. Sanyal draw attention to an early and suitable management of the underlying infection as the only effective management known yet to improve hepatic dysfunc

Sepsis-induced cholestasis

✍ Ivo Giovannini; Carlo Chiarla; Felice Giuliante; Maria Vellone; Francesco Ardito 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 43 KB