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Drug discovery and development for metabolic diseases

✍ Scribed by Rob Hooft

Book ID: 114384571
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 117 KB
Volume: 8
Category: Article
ISSN: 1359-6446
DOI: 10.1016/s1359-6446(03)02919-2

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## Abstract Metabolism by the host organism is one of the most important determinants of the pharmacokinetic profile of a drug. High metabolic lability usually leads to poor bioavailability and high clearance. Formation of active or toxic metabolites will have an impact on the pharmacological and t