Drug development: Raise standards for preclinical cancer research

✍ Scribed by Begley, C. Glenn (author);Ellis, Lee M. (author)

• Book ID: 111671079
• Publisher: Nature Publishing Group
• Year: 2012
• Tongue: English
• Weight: 757 KB
• Volume: 483
• Category: Article
• ISSN: 0028-0836
• DOI: 10.1038/483531a

✦ Synopsis

HISTORY OF SCIENCE Descartes' lost letter tracked using Google p.540 EARTH SYSTEMS Past climates give valuable clues to future warming p.537 AVIAN INFLUENZA Shift expertise to track mutations where they emerge p.534 Raise standards for preclinical cancer research C. Glenn Begley and Lee M. Ellis propose how methods, publications and incentives must change if patients are to benefit. Many landmark findings in preclinical oncology research are not reproducible, in part because of inadequate cell lines and animal models.