00 preface_ Drug Development – A Case Study Based Insight into Modern Strategies......Page 1
00a_Part 1_Novel Approaches to Cancer Treatment......Page 17
01_Discovery and Optimization of
Inhibitors of DNA Methyltransferase as
Novel Drugs for Cancer Therapy......Page 19
02_Development of Novel Secondary
Hormonal Therapies for
Castrate-Resistant Prostate Cancer......Page 39
03_Inhibitors of Proteinases
as Potential Anti-Cancer Agents......Page 55
04_Histamine Receptors as Potential Therapeutic
Targets for Cancer Drug Development......Page 91
05_Histone Deacetylase Inhibitors as
Therapeutic Agents for Cancer
Therapy: Drug Metabolism and
Pharmacokinetic Properties......Page 117
05a_Part 2_ Anti-Infectives......Page 137
06_Antimicrobial Peptides:
New Frontiers in the Therapy of Infections......Page 139
07_microRNAs as Therapeutic Targets to Combat
Diverse Human Diseases......Page 179
08_Potentiation of Available Antibiotics
by Targeting Resistance – An Emerging
Trend in Tuberculosis Drug Development......Page 199
09_Antitubercular Drugs Development:
Recent Advances in Selected Therapeutic
Targets and Rational Drug Design......Page 223
10_Insight into the Key Structural Features
of Potent Enoyl Acyl Carrier Protein
Reductase Inhibitors Based on
Computer Aided Molecular Design......Page 259
10a_Part 3_ Novel Targets and Technologies Leading
to Improved Treatment Options......Page 279
11_RNA Interference-Based Therapeutics:
Harnessing the Powers of Nature......Page 281
12_P2X Receptors as New Therapeutic Targets......Page 329
13_Pregnane X Receptor in Drug Development......Page 353
14_Crosstalk Between the Immune and
Central Nervous Systems with Special
Reference to Drug Development......Page 381
15_Liquiritigenin Attenuates Alzheimer’s-Like
Neuropathology in an Amyloid Protein
Precursor Transgenic Mouse Model
and the Underlying Mechanisms......Page 397
16_Novel Therapeutic Strategies
for Chagas` Disease......Page 415
17_The Gut Microbiota as Target for Innovative
Drug Development: Perspectives and a Case
Study of Inflammatory Bowel Diseases......Page 453
18_Endophytic Fungi of Tropical Forests:
A Promising Source of Bioactive
Prototype Molecules for the
Treatment of Neglected Diseases......Page 485
19_Bioproduction of Depsidones
for Pharmaceutical Purposes......Page 503
20_Multi-Dose Container for Nasal and
Ophthalmic Drugs: A Preservative Free Future?......Page 525
21_Microneedle-Assisted Transdermal
Delivery of Opioid Antagonists
for the Treatment of Alcoholism......Page 541
21a_Part 4_ Drug Development Strategies......Page 559
22_Innovative Proposals for
Incentivizing Drug Development......Page 561
23_Drug Experimentation in Healthy Volunteers......Page 577
24_Changes in Research and Development
of Medicinal Products since
the Paediatric Regulation......Page 601