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Drug Delivery Systems for Tuberculosis Treatment

✍ Scribed by Batyrbekov, Erkesh O.; Rukhina, Larisa B.; Zhubanov, Bulat A.; Bekmukhamedova, Nailya F.; Smailova, Gulnara A.

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
190 KB
Volume
43
Category
Article
ISSN
0959-8103

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✦ Synopsis

Drug delivery systems based on polyurethane have been used for the controlled release of chemotherapeutic agents for the treatment of the chronic microbial disease tuberculosis. The drugs used in the investigation were isoniazid, ethionamide and Γ‘orimicin. An in vitro technique was used to determine the release characteristics of the drugs into model biological media. It was shown that drug release occurs in accordance with Ðrst-order kinetics. The inΓ‘uence of drug loadings on release proÐles was studied. The possibility of application of the drug delivery systems for tuberculosis treatment was shown by some medical and biological tests.

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## Abstract Drugs are now administered at frequencies and doses based on averages optimized for large populations. Because the optimal frequency and dose for an individual differs, transiently or permanently, from that of a population's average, the dosing is necessarily suboptimal. Feedback loop‐b