Drug Delivery Systems

✍ Scribed by Kewal K. Jain

• Publisher: Springer New York;Humana
• Year: 2020
• Tongue: English
• Leaves: 320
• Series: Methods in Molecular Biology 2059
• Edition: 3rd ed. 2020
• Category: Library

✦ Synopsis

This third edition volume expands on the previous editions with a discussion of new and updated methods used to study drug delivery. Chapters cover topics such as drug delivery in cancer and intrathecal delivery of analgesics in humans. The increasing role of nanobiotechnology is reflected in eight of the sixteen chapters that include synthesis of gold nanoparticles; targeted siRNA delivery; and lipid nanocarriers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and thorough, Drug Delivery Systems: Methods and Protocols, Third Edition is a valuable resource for scientists working in industry or academia, and physicians involved in research and clinical care of patients.

✦ Table of Contents

Front Matter ....Pages i-xi
An Overview of Drug Delivery Systems (Kewal K. Jain)....Pages 1-54
Role of Nanobiotechnology in Drug Delivery (Kewal K. Jain)....Pages 55-73
Intrathecal Drug Delivery (José De Andrés, Rubén Rubio-Haro, Carmen De Andres-Serrano, Juan Marcos Asensio-Samper, Gustavo Fabregat-Cid)....Pages 75-108
Microanatomy Relevant to Intrathecal Drug Delivery (Miguel Angel Reina, André Boezaart, Carmen De Andres-Serrano, Rubén Rubio-Haro, José De Andrés)....Pages 109-120
Drug Delivery Applications of Nanoparticles in the Spine (Indu Venugopal, Ankit I. Mehta, Andreas A. Linninger)....Pages 121-143
Synthesis of Gold Nanoparticle: Peptide–Drug Conjugates for Targeted Drug Delivery (K. Kalishwaralal, G. Luboshits, M. A. Firer)....Pages 145-154
A Method for Targeted Nonviral siRNA Delivery in Cancer and Inflammatory Diseases (Rima Kandil, Yuran Xie, Aditi Mehta, Olivia Merkel)....Pages 155-166
Tumor-Targeted Dendrimer Nanoparticles for Combinatorial Delivery of siRNA and Chemotherapy for Cancer Treatment (Narsireddy Amreddy, Rebaz A. Ahmed, Anupama Munshi, Rajagopal Ramesh)....Pages 167-189
Sonoporation for Augmenting Chemotherapy of Pancreatic Ductal Adenocarcinoma (Jason Castle, Spiros Kotopoulis, Flemming Forsberg)....Pages 191-205
Preparation of Cholera Toxin Subunit B Functionalized Nanoparticles for Targeted Therapy of Glioblastoma (Juan Guan, Jun Qian, Changyou Zhan)....Pages 207-212
Microfluidic Manufacturing of Multitargeted PLGA/PEG Nanoparticles for Delivery of Taxane Chemotherapeutics (Cláudia Martins, Bruno Sarmento)....Pages 213-224
Computer-Aided Design of Nanoparticles for Transdermal Drug Delivery (Rakesh Gupta, Beena Rai)....Pages 225-237
Microneedle-Mediated Transdermal Delivery of Tizanidine Hydrochloride (Hetal Thakkar, Kartik Pandya, Brijesh Patel)....Pages 239-258
Targeted siRNA Delivery Using Lipid Nanoparticles (Andreia Jorge, Alberto Pais, Carla Vitorino)....Pages 259-283
Lipid Nanocarriers for Enhanced Delivery of Temozolomide to the Brain (Archana Khosa, Kowthavarapu V. Krishna, Sunil Kumar Dubey, Ranendra Narayan Saha)....Pages 285-298
Construction of a Macrophage-Targeting Bio-nanocapsule-Based Nanocarrier (Hao Li, Masaharu Somiya, Kenji Tatematsu, Shun’ichi Kuroda)....Pages 299-313
Back Matter ....Pages 315-316

✦ Subjects

Chemistry; Biotechnology; Pharmacology/Toxicology