Drug delivery of oligonucleotides by peptides
β Scribed by Dirk Lochmann; Edith Jauk; Andreas Zimmer
- Book ID
- 116437259
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- French
- Weight
- 225 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0939-6411
No coin nor oath required. For personal study only.
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## Abstract For Abstract see ChemInform Abstract in Full Text.
Oligonucleotides (ONs) are a new class of therapeutic compounds under investigation for the treatment of a variety of disease states, such as cancer and HIV, and for FDA approval of an anti-CMV retinitis antisense molecule (Vitravene trade mark, Isis Pharmaceuticals). However, these molecules are li
## Abstract The discovery of cellβpenetrating peptides as gene delivery systems and the interest in the mechanism by which these vectors cross the cell membrane have generated a large number of studies. Among the parameters involved in the translocation process, controversy has arisen about the rol