Drug Delivery by an Enzyme-Mediated Cyclization of a Lipid Prodrug with Unique Bilayer-Formation Properties

✍ Scribed by Lars Linderoth; Günther H. Peters; Robert Madsen; Thomas L. Andresen

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 408 KB
• Volume: 48
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200805241

✦ Synopsis

Abstract

Special delivery: Liposomal drug‐delivery systems in which prodrugs are activated specifically by disease‐associated enzymes have great potential for the treatment of severe diseases, such as cancer. A new type of phospholipid‐based prodrug has the ability to form stable small unilamellar vesicles (see picture). Activation of the prodrug vesicles by the enzyme sPLA~2~ initiates a cyclization reaction, which leads to the release of the drug.magnified image