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DrosophilaCK2 phosphorylates Deadpan, a member of the HES family of basic-helix-loop-helix (bHLH) repressors

✍ Scribed by Umesh C. Karandikar; Jonathan Shaffer; Clifton P. Bishop; Ashok P. Bidwai


Book ID
106457489
Publisher
Springer
Year
2005
Tongue
English
Weight
234 KB
Volume
274
Category
Article
ISSN
0300-8177

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HES-1 is a vertebrate homologue of the Drosophila basic helix-loop-helix (bHLH) protein Hairy, a transcriptional repressor that negatively regulates neuronal differentiation. HES-1 expression in neuronal precursors precedes and represses the expression of the neuronal commitment gene MASH-1, a bHLH