Drosophilaalcohol dehydrogenase activityin vitroandin vivo: Effects of acetone feeding

✍ Scribed by Ira Papel; Melford Henderson; Jeanine Herrewege; Jean David; William Sofer

• Book ID: 104787361
• Publisher: Springer
• Year: 1979
• Tongue: English
• Weight: 532 KB
• Volume: 17
• Category: Article
• ISSN: 0006-2928
• DOI: 10.1007/bf00498890

✦ Synopsis

When adult Drosophila are placed on medium containing 0.5%0 acetone, their level of alcohol dehydrogenase activity drops rapidly. At the same time, the proportion of activity in the various electrophoretic forms of the enzyme shifts; most of the activity becomes localized in what is ordinarily a minor form of the enzyme. Moreover, the loss of enzyme activity occurs in vivo as well, as shown by sensitivity to ethanol poisoning, insensitivity to pentenol treatment, and inability to utilize ethanol as an energy source. These observations are discussed in light of a model advanced for the origin of the multiple forms of alcohol dehydrogenase in Drosophila.