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Drop of connexin 43 in replicative senescence of human fibroblasts HEL-299 as a possible biomarker of senescence

โœ Scribed by Massimo Statuto; Cristina Bianchi; Roberto Perego; Ugo Del Monte


Book ID
114253758
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
264 KB
Volume
37
Category
Article
ISSN
0531-5565

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EPC-1 (early population doubling level cDNA-1) is a quiescence-specific gene expressed at high levels by early passage WI-38 fibroblasts under conditions of either density-dependent growth arrest or serum deprivation. Late passage WI-38 cells lose the ability to express EPC-1 under all conditions te