Asymmetric 13-dipolar cycloaddition of n
โ
Jean-Paul G. Seerden; Anita W.A. Schotte op Reimer; Hans W. Scheeren
๐
Article
๐
1994
๐
Elsevier Science
๐
French
โ 357 KB
## Asymmetric 1.3-dipolar cycioad@ion of n&ones with ketenc acetals is strongly catalyzed by chiral oxazaborolidines d&ived from N-tosyl-L-a-amino acids. The 5,5dialkoxyisoxuzolidines are obtained regioselectively in high yield wish high stereoselectivity and moderate enantioselectivity up to 62% ee