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Dragmacidin F: A New Antiviral Bromoindole Alkaloid from the Mediterranean Sponge Halicortex sp.

✍ Scribed by Adele Cutignano; Giuseppe Bifulco; Ines Bruno; Agostino Casapullo; Luigi Gomez-Paloma; Raffaele Riccio

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
108 KB
Volume
56
Category
Article
ISSN
0040-4020

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✦ Synopsis

AbstractÐA new bromoindole alkaloid, named dragmacidin F (1) and structurally related to other dragmacidins previously described, was isolated from a marine sponge of the genus Halicortex collected off the southern coast of Ustica Island (Italy). Structural elucidation of 1 was achieved by an extensive spectroscopic study (mainly by 1D/2D-NMR and MS techniques). Compound 1, containing an unprecedented carbon skeleton that is very likely derived from cyclization of a partially oxidized form of dragmacidin D (2), showed in vitro antiviral activity against HSV-1 (EC 50 95.8 mM) and HIV-1 (EC 50 0.91 mM), thus proving to be responsible for the antiviral property exhibited by Halicortex extracts.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Dragmacidin F: A Ne
ChemInform Abstract: Dragmacidin F: A New Antiviral Bromoindole Alkaloid from the Mediterranean Sponge Halicortex sp.
✍ Adele Cutignano; Giuseppe Bifulco; Ines Bruno; Agostino Casapullo; Luigi Gomez-P πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons βš– 27 KB πŸ‘ 1 views

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