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Doxorubicin resistant neuroblastoma cells secrete factors that activate AKT and attenuate cytotoxicity in drug-sensitive cells

✍ Scribed by Mohammad A. Emran; Abdelhadi Rebbaa; Bernard L. Mirkin

Book ID: 117467329
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 220 KB
Volume: 182
Category: Article
ISSN: 0304-3835
DOI: 10.1016/s0304-3835(02)00062-9

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## Abstract Tumor cells chronically exposed to cisplatin (cDDP) acquire cDDP resistance that impacts tumor therapy. To elucidate the mechanism of acquired cDDP resistance (ACR), we compared HeLa cells that gained ACR upon chronic cDDP treatment with the parental strain. We show that ACR is due to a