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Doxorubicin inhibits TGF-β signaling in human lung carcinoma A549 cells

✍ Scribed by Yevhen Filyak; Oksana Filyak; Serhiy Souchelnytskyi; Rostyslav Stoika

Book ID
113587663
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
884 KB
Volume
590
Category
Article
ISSN
0014-2999

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Transforming growth factor-␤ (TGF-␤) is a potent inducer of numerous extracellular matrix components, largely through a transcriptional mechanism. To define the postreceptor signaling pathways used by TGF-␤ in the induction of extracellular matrix gene expression, we have utilized the human lung car