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Doxorubicin-induced apoptosis in human T-cell leukemia is mediated by caspase-3 activation in a Fas-independent way

✍ Scribed by Susana Gamen; Alberto Anel; Pilar Lasierra; Marı́a A Alava; Maria José Martinez-Lorenzo; Andrés Piñeiro; Javier Naval

Book ID: 117108367
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 616 KB
Volume: 417
Category: Article
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(97)01282-9

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## Abstract Osteosarcoma is one of the most common primary malignant tumors of bone. Treatment of this tumor with systemic chemotherapy dramatically improves the prognosis, although the molecular mechanisms involved in the drug action are poorly understood. In chemosensitive leukaemic T cells and c