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Doxorubicin immunoconjugates containing bivalent, lysosomally-Cleavable dipeptide linkages

โœ Scribed by Gene M Dubowchik; Shilpa Radia; Harold Mastalerz; Michael A Walker; Raymond A Firestone; H Dalton King; Sandra J Hofstead; David Willner; Shirley J Lasch; Pamela A Trail


Book ID
108477207
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
133 KB
Volume
12
Category
Article
ISSN
0960-894X

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Hepatocyte-targeting and shell cross-linked nanoparticles with lactose moiety on the surface and doxorubicin (DOX) in the core were prepared from lactose-PEG-DOX conjugate. The process consists of the synthesis of a novel ฮฑ-hydrazine-ฯ‰-propargyl poly(ethylene glycol) (PEG) with a double bond in the