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Doxorubicin decomposition on storage. Effect of pH, type of buffer and liposome encapsulation

✍ Scribed by JANSSEN, M; CROMMELIN, D; STORM, G; HULSHOFF, A


Book ID
120485736
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
756 KB
Volume
23
Category
Article
ISSN
0378-5173

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Background. The authors compared the therapeutic effects of doxorubicin in two formulations: free in saline suspension and encapsulated in sterically stabilized liposomes composed of hydrogenated soy phosphatidylcholine/2cholesterol/polyethylene glycol-distearoyl-phosphatidyl-ethanolamine (Doxil, Li