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Doxorubicin-conjugated biodegradable polymeric micelles having acid-cleavable linkages

✍ Scribed by Hyuk Sang Yoo; Eun Ah Lee; Tae Gwan Park

Book ID: 114161756
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 841 KB
Volume: 82
Category: Article
ISSN: 0168-3659
DOI: 10.1016/s0168-3659(02)00088-3

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Biodegradable polymeric micelles containing doxorubicin in the core region were prepared from a di-block copolymer composed of doxorubicin-conjugated poly(DL-lactic-co-glycolic acid) (PLGA) and polyethyleneglycol (PEG). The di-block copolymer of PLGA-PEG was first synthesized and the primary amino g