Doxazosin in patients with hypertension
β Scribed by K. A. Conrad; T. C. Fagan; M. J. Mackie; P. V. Mayshar; S. Lee; J. F. Souhrada; F. C. Falkner; J. D. Lazar
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 423 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0031-6970
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Disturbances in the fibrinolytic system have been associated with cardiovascular disease and its risk factors. In the present study the effects of an alpha 1-adrenoceptor inhibitor (doxazosin) and a selective beta-adrenoceptor blocker (atenolol) on the fibrinolytic system have been evaluated. Eighty
Doxazosin (mean dose 11 mg) given once daily in combination with 100 mg atenolol (n = 44) was compared with placebo and atenolol (n = 43) in a double-blind, multicenter study in patients with mild to moderate essential hypertension. In the atenolol/doxazosin-treated group, standing blood pressure si