Downregulation of the reduced folate carrier transport activity by phenobarbital-type cytochrome P450 inducers and protein kinase C activators

Docosahexaenoic acid downregulates pheno

Docosahexaenoic acid downregulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes via the c-Jun NH2-terminal kinase mitogen-activated protein kinase pathway

✍ Chia-Yang Lu; Chien-Chun Li; Kai-Li Liu; Chong-Kuei Lii; Haw-Wen Chen 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 840 KB

## Abstract Mitogen‐activated protein kinase (MAPK) pathways play central roles in the transduction of extracellular stimuli into cells and the regulation of expression of numerous genes. Docosahexaenoic acid (DHA) was shown to be involved in the regulation of expression of drug metabolizing enzyme