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Downregulation of the ERK 1 and 2 mitogen activated protein kinases using antisense oligonucleotides inhibits proliferation of porcine vascular smooth muscle cells

โœ Scribed by M Fisher; B Liu; P.E Glennon; K.M Southgate; E.M Sale; G.J Sale; M.J Lewis; P.H Groves


Book ID
119434089
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
195 KB
Volume
156
Category
Article
ISSN
0021-9150

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## Abstract Chronic oxidative injury by allylamine (AAM) induces proliferative vascular smooth muscle cell (vSMC) phenotypes in the rat aorta similar to those seen in rodent and human atherosclerotic lesions. The proliferative advantage of AAM vSMC compared to control cells is maintained with seria