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Downregulation of protein kinase C-γ is independent of a functional kinase domain

✍ Scribed by Ina Freisewinkel; Dieter Riethmacher; Silvia Stabel

Book ID
115924628
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
841 KB
Volume
280
Category
Article
ISSN
0014-5793

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C1 domains are compact alpha/beta structural units of about 50 amino acids which tightly bind two zinc ions. These domains were first discovered as the loci of phorbol ester and diacylglycerol binding to conventional protein kinase C isozymes, which contain 2 C1 domains (C1A and C1B) in their N-term