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Downregulation of phosphodiesterase 4B (PDE4B) activates protein kinase A and contributes to the progression of prostate cancer

✍ Scribed by Eiji Kashiwagi; Masaki Shiota; Akira Yokomizo; Momoe Itsumi; Junichi Inokuchi; Takeshi Uchiumi; Seiji Naito


Book ID
112179556
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
498 KB
Volume
72
Category
Article
ISSN
0270-4137

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## Abstract The synthetic retinoid __N__‐(4‐hydroxyphenyl)retinamide (4‐HPR) has been shown to induce apoptosis in various types of tumors, including prostate cancer. We sought to examine the key mechanisms affecting the resistance to 4‐HPR–induced apoptosis in three human prostate cancer cell line