✦ LIBER ✦

Downregulation of phorbol 12-myristate 13-acetate–induced tumor necrosis factor–alpha and interleukin-1β production and gene expression in human monocytic cells by human alpha-fetoprotein

✍ Scribed by Wei Wang; Elliot Alpert

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 896 KB
Volume: 22
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840220333

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✦ Synopsis

We previously identified a specific receptor for alphafetoprotein (AFP) on human monocytes. Although AFP alters many immune cell functions, the effect of AFP on monocyte cytokine production is unknown. Because tumor necrosis factor-alpha (TNF-a) and interleukin-lj3 (IL-lp) are important cytokines in immunoregulation, we investigated whether AFP could modulate TNF-a and IL-lP production in U937, a human monocytic cell line.

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