## Abstract Resistance to tumor necrosis factor (TNFα)‐induced apoptosis in various cancer cells has been attributed to the activation of the transcription factor NF‐κB. Ebselen (2‐phenyl‐1,2‐benzisoselenazol‐3[2H]one)—a selenoorganic compound is known to prevent TNFα‐mediated NF‐κB activity. As gl
✦ LIBER ✦
Downregulation of NF-κB signaling by mutant huntingtin proteins induces oxidative stress and cell death
✍ Scribed by Sami Reijonen; Jyrki P. Kukkonen; Alise Hyrskyluoto; Jenny Kivinen; Minna Kairisalo; Nobuyuki Takei; Dan Lindholm; Laura Korhonen
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 748 KB
- Volume
- 67
- Category
- Article
- ISSN
- 1420-682X
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## Abstract Cutaneous and ocular injuries caused by sulfur mustard (SM; bis‐(2‐chloroethyl) sulfide) are characterized by severe inflammation and death of exposed cells. Given the known roles of p38MAPK and NF‐κB in inflammatory cytokine production, and the known roles of NF‐κB and p53 in cell fate