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Downregulation of Mcl-1 by daunorubicin pretreatment reverses resistance of breast cancer cells to TNF-related apoptosis-inducing ligand

✍ Scribed by Bora Oh; SoJung Park; Jhang Ho Pak; InKi Kim


Book ID
116303380
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
749 KB
Volume
422
Category
Article
ISSN
0006-291X

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## Abstract __Pseudomonas__ exotoxin (PE)–containing immunotoxins (ITs) act by arresting protein synthesis and promoting apoptosis, but the mechanisms of the induced apoptosis and the relationship to protein synthesis inhibition is not well elucidated. We studied these effects in MA‐11 human breast