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Downregulation of human polo-like kinase activity by antisense oligonucleotides induces growth inhibition in cancer cells

✍ Scribed by Spänkuch-Schmitt, Birgit; Wolf, Georg; Solbach, Christine; Loibl, Sibylle; Knecht, Rainald; Stegmüller, Manfred; von Minckwitz, Gunter; Kaufmann, Manfred; Strebhardt, Klaus

Book ID
110066606
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
418 KB
Volume
21
Category
Article
ISSN
0950-9232

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## Abstract Members of the polo‐like kinases (Plk1, Plk2, Plk3 and Plk4) are involved in the regulation of various stages of the cell cycle and have been implicated in cancer progression. Unlike its other family members, the expression of Plk3 remains steady during cell cycle progression, suggestin