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Downregulation of Hsp27 (HSPB1) in MCF-7 human breast cancer cells induces upregulation of PTEN

✍ Scribed by Cayado-Gutiérrez, Niubys; Moncalero, Vera L.; Rosales, Eliana M.; Berón, Walter; Salvatierra, Edgardo E.; Alvarez-Olmedo, Daiana; Radrizzani, Martín; Ciocca, Daniel R.

Book ID
120167096
Publisher
Springer Netherlands
Year
2012
Tongue
English
Weight
469 KB
Volume
18
Category
Article
ISSN
1355-8145

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We report here that the antiestrogen tamoxifen (TAM) induces cell death in human breast cancer cell line MCF-7. We assessed the type of cell death induced by TAM in this breast cancer cell line on the basis of morphological and biochemical characteristics. Dying cells showed morphological characteri