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Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera

โœ Scribed by Orly Weizer-Stern; Konstantin Adamsky; Ninette Amariglio; Carina Levin; Ariel Koren; William Breuer; Eliezer Rachmilewitz; Laura Breda; Stefano Rivella; Z. Ioav Cabantchik; Gideon Rechavi

Book ID
108673921
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
663 KB
Volume
135
Category
Article
ISSN
0007-1048

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## Abstract Primary cultures of human hepatocytes and hepatoma cell line HepG2 are frequently used to evaluate the hepatic disposition of drugs and other xenobiotics. To check the variability of the expression of drugโ€metabolizing enzymes in these in vitro models, expression of genes coding for sev