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Downregulation of hepatoma-derived growth factor activates the Bad-mediated apoptotic pathway in human cancer cells

✍ Scribed by Tsun Yee Tsang; Wan Yee Tang; Wing Pui Tsang; Ngai Na Co; Siu Kai Kong; Tim Tak Kwok


Publisher
Springer
Year
2008
Tongue
English
Weight
755 KB
Volume
13
Category
Article
ISSN
1360-8185

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Transforming growth factor ␀ (TGF-␀) has been shown to induce apoptotic cell death in normal and transformed hepatocytes. However, the exact mechanism through which TGF-␀ induces cell death is still unknown. We examined a potential role of various death receptor/ ligand systems in TGF-␀-induced apop