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Downregulation of bcl-2 expression in lymphoma cells by bcl-2 ARE-targeted modified, synthetic ribozyme

✍ Scribed by Luzi, Ettore; Papucci, Laura; Schiavone, Nicola; Donnini, Martino; Lapucci, Andrea; Tempestini, Alessio; Witort, Ewa; Nicolin, Angelo; Capaccioli, Sergio


Book ID
110018972
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
190 KB
Volume
10
Category
Article
ISSN
0929-1903

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## Abstract Targeting tumor‐related overexpression of anti‐apoptotic __Bcl2__ protein by RNAi has been suggested as a potential treatment for cancer. However, the stability of RNAi and its delivery are still major obstacles to the clinical testing of __Bcl2__ RNAi. Here, we explore a novel strategy