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Downexpression of aldehyde dehydrogenase 1 in murine lung tumors

✍ Scribed by Tommaso A. Dragani; F. Stefania Falvella; Giacomo Manenti; Marco A. Pierotti; Romolo A. Gambetta

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
665 KB
Volume
16
Category
Article
ISSN
0899-1987

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✦ Synopsis

We analyzed the expression of the cytosolic aldehyde dehydrogenase 1 (Aldhl) gene in mouse lung tumors by northern blotting and immunocytochemical analysis. AIdhl was abundantly expressed in normal lung tissue, with a predominant cellular localization on bronchiolar cells. However, expression of Aldhl was strongly reduced (more than tenfold) in lung tumors. As aldehyde dehydrogenases metabolize some antitumor alkylating drugs to inactive compounds, the low expression of Aldhl in lung tumors may account for the drug sensitivity of these tumors to chemotherapeutic agents.

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