We appreciate the interest of James [1996] in our recent report [Castilla et al., 19951. Of course, it is selfevident that definitively assessing the deleterious effect of aging gametes requires a more rigorous study design, namely, a cohort study in which date of conception is correlated with subse
β¦ LIBER β¦
Down syndrome and natural family planning
β Scribed by James, William H.
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 131 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0148-7299
No coin nor oath required. For personal study only.
β¦ Synopsis
Castilla et al. [1995] report that users of natural family planning (NFP) produced no excess of Down syndrome (DS) infants. The finding is relevant to the question of whether DS is sometimes the consequence of the fertilization of an oocyte which is "overripe." That question achieved prominence in the hypothesis of German [ 19681 that the decline in coital rate with maternal age results in a rise in the proportion of such late fertilizations, thus accounting for the maternal age effect in DS. It was shown mathematically that this decline
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