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Down regulation of the L-type Ca2+ channel, GRK2, and phosphorylated phospholamban: protective mechanisms for the denervated failing heart

โœ Scribed by A. Yatani; Y.-T. Shen; L. Yan; W. Chen; S.-J. Kim; K. Sano; K. Irie; S.F. Vatner; D.E. Vatner


Book ID
116983829
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
673 KB
Volume
40
Category
Article
ISSN
0022-2828

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Mechanism of down-regulation of L-type C
โœ Eikichi Ihara; Katsuya Hirano; Mayumi Hirano; Junji Nishimura; Hajime Nawata; Hi ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 223 KB

The mechanism of down-regulation of L-type Ca(2+) channel (L-VOC) was investigated in rat aortic smooth muscle cells in primary culture. On culture days 3-5, the cells actively incorporated the 5-bromo-2'-deoxy-uridine (BrdU), and did not respond to K(+) depolarization nor express alpha(1C) subunit