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Down-regulation of Receptor-mediated Endocytosis Is Reponsible for Senescence-associated Hyporesponsiveness

โœ Scribed by SANG CHUL PARK; JEONG-SOO PARK; WOONG-YANG PARK; KYOUNG-A CHO; JEONG SOO AHN; IK SOON JANG


Book ID
110108308
Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
725 KB
Volume
959
Category
Article
ISSN
0890-6564

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CD45 is a transmembrane protein tyrosine phosphatase required for signaling through the Tand B-cell antigen receptors. In lymphocytes, CD45 interacts with CD45-associated protein (CD45AP), a 32 000 Mr phosphoprotein, through their respective transmembrane domains. To determine whether CD45AP affects