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Down-regulation of protein kinase C isoforms in irritant contact dermatitis

✍ Scribed by Li, Lin-feng; Fiedler, Virginia C.; Kumar, Raj

Book ID: 119562715
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 167 KB
Volume: 16
Category: Article
ISSN: 0923-1811
DOI: 10.1016/s0923-1811(98)83935-2

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Protein kinase C (PKC) comprises a family of related phospholipid-dependent serine/threonine protein kinases. PKC is important in signal transduction, regulating cell proliferation and differentiation. Recently, it has also been suggested that PKC may play a part in the pathogenesis of contact derma