Down-regulation of protein kinase C activation in human lamina propria T lymphocytes: Influence of intestinal mucosa on T cell reactivity

Response of alkalinization or acidificat

Response of alkalinization or acidification by phytohemagglutinin is dependent on the activity of protein kinase C in human peripheral T Cells

✍ Eileen Jea Chien; Dennis J-Y Hsieh; John E-C Wang 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 180 KB 👁 1 views

## Abstract The increase of intracellular free calcium concentration ([Ca^2+^]~i~) and protein kinase C (PKC) activity are two major early mitogenic signals to initiate proliferation of human T cells. However, a rapid change in intracellular pH (pH~i~), acidification or alkalinization during the ac