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Down-regulation of NDRG2 gene expression in human colorectal cancer involves promoter methylation and microRNA-650

โœ Scribed by Li Feng; Yun Xie; Hao Zhang; Yunlin Wu


Book ID
116301473
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
786 KB
Volume
406
Category
Article
ISSN
0006-291X

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## Abstract Nonrandom, widespread promoter methylation of tumor suppressor genes is a common mechanism of gene inactivation during tumorigenesis. We examined the methylation status of two distinct regions of the __MLH1__ promoter (proximal and distal to the transcription start site) and the __MLH1_