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Down-Regulation of N-Type Voltage-Activated Ca2+Channels by Gabapentin

✍ Scribed by Alfonso Vega-Hernández; Ricardo Felix

Book ID
110391252
Publisher
Springer
Year
2002
Tongue
English
Weight
97 KB
Volume
22
Category
Article
ISSN
0272-4340

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The beta-adrenergic cascade is important for the regulation of voltage-dependent Ca channels by phosphorylation. Here we report that isoproterenol (ISO) profoundly alters the voltage-dependent properties of L-type Ca channels studied in rat ventricular cells. ISO (1 microM) shifted both threshold an