Neuroinflammatory diseases are associated with increased production of matrix metalloproteinase-9 (MMP-9) and excessive generation of nitric oxide (NO). NO has been reported to have variable effects on MMP-9 gene expression and activation in various cell types. In the present study, we investigated
Down-regulation of matrix metalloproteinase-9 expression by nitric oxide in lipopolysaccharide-stimulated rat primary astrocytes
β Scribed by Chan Young Shin; Woo Jong Lee; Ji Woong Choi; Min Sik Choi; Jae Ryun Ryu; Soon Jin Oh; Jae Hoon Cheong; Eui Yul Choi; Kwang Ho Ko
- Book ID
- 116790340
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 254 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1089-8603
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In the present study, we investigated whether the activation of protein kinase C (PKC) and extracellular signal-regulated kinase 1/2 (Erk1/2) are involved in the induction of MMP-9 in lipopolysaccharide (LPS)-stimulated primary astrocytes. The expression of MMP-9 but not MMP-2 was increased by LPS.
The present work was undertaken to study the effect of bacterial lipopolysaccharide (LPS), a potent activator of the host inflammatory response, on the synthesis of nerve growth factor (NGF) by newborn rat brain astrocytes. Treatment of primary rat astroglial cells cultured in chemically defined med