✦ LIBER ✦

Down-regulation of Jagged-1 induces cell growth inhibition and S phase arrest in prostate cancer cells

✍ Scribed by Yuxiang Zhang; Zhiwei Wang; Fakhara Ahmed; Sanjeev Banerjee; Yiwei Li; Fazlul H. Sarkar

Publisher: John Wiley and Sons
Year: 2006
Tongue: French
Weight: 626 KB
Volume: 119
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.22077

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✦ Synopsis

Notch is an ancient cell signaling system that regulates cell fate specification, stem cell maintenance and initiation of differentiation in many tissues. It has been reported that Jagged-1, a Notch ligand, is significantly over expressed in metastatic prostate cancer compared to localized prostate cancer or benign prostatic tissues. Therefore, deregulation of Jagged-1 protein levels may play a role in prostate cancer cell growth and progression. Hence, the aim of our current study was to investigate the mechanistic role of Jagged-1 in prostate cancer cell growth and cell cycle progression. Our results show, for the first time, that down-regulation of Jagged-1 induces cell growth inhibition and S phase cell cycle arrest in prostate cancer cells, with reduced CDK2 kinase activity and increased p27 expression. These results suggest that Jagged-1 could be a potential therapeutic target for the treatment of prostate cancer.

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