Renal sodium retention and potassium loss occur early, in many instances in the preascitic state of cirrhosis, an observation that cannot be fully explained by increased aldosterone concentrations. We therefore hypothesize that 11-hydroxysteroid dehydrogenase 2 (11-HSD2), which protects mineraloco
✦ LIBER ✦
Down-regulation of hepatic and renal 11β-hydroxysteroid dehydrogenase in rats with liver cirrhosis
✍ Scribed by Geneviève Escher; Andrea Nawrocki; Thomas Staub; Bannikuppe S. Vishwanath; Brigitte M. Frey; Jürg Reichen; Felix J. Frey
- Book ID
- 118520590
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 309 KB
- Volume
- 114
- Category
- Article
- ISSN
- 0016-5085
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## Abstract Renal 11β‐hydroxysteroid dehydrogenase 2 (HSD2) catalyzes the conversion of active glucocorticoids to inert 11β‐keto compounds, thereby preventing the illicit binding of these hormones to mineralocorticoid receptors (MRs) and, thus, conferring aldosterone specificity. Absence or inhibit
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