Down-regulation of expression of rat pyruvate dehydrogenase E1α gene by self-complementary adeno-associated virus-mediated small interfering RNA delivery

Intra-articular gene delivery and expres

Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus

✍ Jesse D. Kay; Elvire Gouze; Thomas J. Oligino; Jean-Noel Gouze; Rachael S. Watso 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 269 KB

## Abstract ## Background The adeno‐associated virus (AAV) has many safety features that favor its use in the treatment of arthritic conditions; however, the conventional, single‐stranded vector is inefficient for gene delivery to fibroblastic cells that primarily populate articular tissues. This