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Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis

✍ Scribed by C Gartung; M Ananthanarayanan; MA Rahman; S Schuele; S Nundy; CJ Soroka; A Stolz; FJ Suchy; JL Boyer


Book ID
119755243
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
338 KB
Volume
110
Category
Article
ISSN
0016-5085

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Down-regulation of the organic cation tr
✍ Gerald U. Denk; Carol J. Soroka; Albert Mennone; Hermann Koepsell; Ulrich Beuers πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 200 KB

The liver plays a major role in biotransformation and elimination of various therapeutic agents and xenobiotics, many of which are organic cations and substrates of the organic cation transporter 1 (Oct1, Slc22a1). Oct1 is expressed at the basolateral membranes of hepatocytes and proximal renal tubu