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Down-regulation of Cdk inhibitor p27 in oral squamous cell carcinoma

✍ Scribed by Yasusei Kudo; Shojiro Kitajima; Ikuko Ogawa; Mutsumi Miyauchi; Takashi Takata


Book ID
113832437
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
456 KB
Volume
41
Category
Article
ISSN
1368-8375

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p27 is a cell cycle inhibitor whose cellular abundance increases in response to many antimitogenic stimuli. In this review, we summarize the current knowledge on p27 function and its regulation by synthesis and by ubiquitin-mediated degradation. Importantly, p27 degradation is enhanced in many aggre