Down Regulation of C-MYC and MAX Genes Is Associated to Inhibition of Protein Phosphatase 2A in K562 Human Leukemia Cells
โ Scribed by A. Lerga; B. Belandia; M.D. Delgado; M.A. Cuadrado; C. Richard; J.M. Ortiz; J. Martinperez; J. Leon
- Book ID
- 115577467
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 383 KB
- Volume
- 215
- Category
- Article
- ISSN
- 0006-291X
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## Abstract Fas and FasL expression upregulation was found in human leukemia K562 cells upon exposure to __Naja naja atra__ phospholipase A~2~ (PLA~2~). PLA~2~ treatment induced an increase in intracellular Ca^2+^ ([Ca^2+^]i) and ROS generation levels, leading to activation of p38 MAPK and JNK. Sup