Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region
✍ Scribed by Magdinier, Frédérique; Ribieras, Stéphane; Lenoir, Gilbert M; Frappart, Lucien; Dante, Robert
- Book ID
- 110061715
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 426 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Changes in DNA methylation patterns are frequently observed in human cancers and are associated with a decrease in tumor suppressor gene expression. Hypermethylation of the __BRCA1__ promoter has been reported in a portion of sporadic breast tumours that correspond to a reduction in __B
## Abstract Nonrandom, widespread promoter methylation of tumor suppressor genes is a common mechanism of gene inactivation during tumorigenesis. We examined the methylation status of two distinct regions of the __MLH1__ promoter (proximal and distal to the transcription start site) and the __MLH1_