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Down-regulation of basic fibroblast growth factor production from cartilage by excessive mechanical stress

✍ Scribed by Yutaka Fujiwara; Masaaki Uesugi; Tomoyuki Saito


Book ID
106233388
Publisher
Springer Japan
Year
2005
Tongue
English
Weight
586 KB
Volume
10
Category
Article
ISSN
0949-2658

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Background. Angiogenesis is crucial for tumor growth and metastasis. In several tumors, microvascular density has been shown to correlate with metastasis and aggressiveness. Basic fibroblast growth factor (bFGF) has potent angiogenic activity and has been identified in a wide variety of malignancies