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Down modulation of topoisomerase I affects DNA repair efficiency

✍ Scribed by Yinghui Mao; Mark T Muller

Book ID
117799000
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
288 KB
Volume
2
Category
Article
ISSN
1568-7864

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## Abstract In this report we show that human DNA Topoisomerase I (Top1) forms DNA‐protein adducts with nicked and gapped DNA structures lacking a conventional Top1 cleavage site. The radioactively labeled crosslinking products were identified by SDS‐gel electrophoresis. The chemical structure of t